Catastrophic antiphospholipid syndrome (Ronald Asherson syndrome) and obstetric pathology-Reference-Cited by-同舟云学术

Catastrophic antiphospholipid syndrome (Ronald Asherson syndrome) and obstetric pathology

Published:2017-08-22 Issue:4 Volume:46 Page:387-400
ISSN:1619-3997
Container-title:Journal of Perinatal Medicine
language:en
Short-container-title:

Author:

Makatsariya Alexander D.¹,Khizroeva Jamilya²,Bitsadze Viktoriya O.²

Affiliation:

1. Correspondent Member of the Russian Academy of Sciences , Head of the Chair of Obstetrics and Gynecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical University, Vice-President of Russian Association of Obstetricians and Gynaecologists , Dmitrii Ulyanov Street 4-2-432 , 119333 Moscow , Russia , Tel.: +7(903)728-0897

2. Professors of the Chair of Obstetrics and Gynecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical University , Zemlyanoi Val, 62 , 109004 Moscow , Russia

Abstract

Abstract Background: Catastrophic antiphospholipid syndrome (CAPS) is an uncommon, often fatal, variant of the antiphospholipid syndrome (APS) that results in a widespread coagulopathy and high titres of antiphospholipid antibodies (aPL) and affects predominantly small vessels supplying organs with the development of multiorgan failure. It remains unclear why some patients develop the typical clinical picture of APS (thrombosis of large vessels), whereas others show the development of progressive microthrombosis, which the authors called “thrombotic storm” and multiple organ failure, that is, CAPS. Materials and methods: Since 2001–2016, we discovered 17 patients with CAPS development. Conclusion: CAPS is life-threatening condition, but optimal treatment for CAPS is not developed yet and the mortality rate is as high as 30%–40%.

Publisher

Walter de Gruyter GmbH

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpm-2017-0092/pdf

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