Affiliation:
1. 1National Institute of Diabetes, Nutrition and Metabolic Diseases “Prof. Dr. N.C. Paulescu”, Bucharest, Romania Romania
2. 2National Institute of Research and Development for Food Bioresource (IBA), Bucharest, Romania
3. 3University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
4. 4National Institute of Diabetes, Nutrition and Metabolic Diseases “Prof. Dr. N.C. Paulescu”, Bucharest, Romania
Abstract
AbstractBackground and Aims. Diabetes mellitus and obesity modify the resting metabolic rate (RMR) in opposite directions. This study aimed to evaluate the relationship between RMR, insulin activity and adipocytokines in type 2 diabetes patients with associated obesity. Material and Method. Anthropometric and biochemical measurements, bioimpedance body composition, C peptide, insulin, proinsulin, adiponectin, leptin, indirect calorimetry measured RMR were determined in 306 (53% male, 54.9% obese) diabetic patients. Results. RMR, C peptide, insulin, proinsulin, Homeostasis Model Assessment (HOMA) IR, HOMA %B, leptin increased and adiponectin decreased with body mass index (BMI). BMI had a statistical significant higher effect size on fat mass (FM), leptin (0.652-0.339 eta squared), moderate positive effect size on fat-free mass (FFM), insulin, C peptide, RMR, HOMA %B (0.228 - 0.155 eta squared) and lower effect size on HOMA-IR, adiponectin, proinsulin-to-adiponectin ratio, proinsulin (0.098-0.062 eta squared). RMR had positive correlations with FFM (r=0.633), BMI (r=0.300), proinsulin-to-adiponectin ratio (r=0.218), HOMA1-IR (r=0.176), proinsulin (r=0.151), insulin (r=0.144), fasting plasma glucose (r=0.132), fat mass (r= 0.131), triglycerides (r = 0.119), proinsulin-to-insulin ratio (r= 0.117) and negative with age (r=-0.368), HDL cholesterol (r=-0.284), adiponectin(r=-0.282) and leptin (r=-0.178). Conclusions RMR was correlated with HOMA IR and insulin resistance biomarkers, but not with HOMA %B and C peptide.
Reference52 articles.
1. peptidebased index is more related to incident type diabetes in non - diabetic subjects than insulin - based index;Kim;Endocrinol Metab Seoul,2016
2. Initiative Expert Panel on the Identification Evaluation and Treatment of Obesity in Adults US Clinical guidelines on the identification evaluation and treatment of overweight and obesity in adults The evidence report NIH publication No Accessed at : https;NHLBI;Obesity Education Sept,1998
3. body fat distribution insulin sensitivity and islet beta - cell function as explanations for metabolic diversity;Kahn;Obesity J Nutr,2001
4. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism;Tschritter;Diabetes,2003
5. Initiative Expert Panel on the Identification Evaluation and Treatment of Obesity in Adults US Clinical guidelines on the identification evaluation and treatment of overweight and obesity in adults The evidence report NIH publication No Accessed at : https;NHLBI;Obesity Education Sept,1998