Raw Camel Milk Properties on Alloxan-Induced Diabetic Wistar Rats

Abstract

Abstract Background and aims: Diabetes is one of the most frequent and serious chronic diseases in humans all over the world. The aim of our study was to evaluate the antidiabetic activity of camel milk on serum glucose and lipid profile of alloxan-induced diabetic rats. Materials and methods: Diabetes was induced in Wistar albino rats by intraperitoneal injection of alloxan (120 mg/kg BW once). Albino rats each weighing 180-230g were divided into 3 equal groups (n=10) as following: G1 - normal rats fed on normal diet, G2 - diabetic rats fed on normal diet, and G3 - diabetic rats were fed with raw camel milk. Fasting blood glucose was measured on days 0, 1, 7, 14, 21 and 30 while lipid profile was assessed at day 30. Results: After four weeks of feeding, data indicated a significant decrease (p<0.05) of mean blood glucose in G3 group (133.80±3.22 mg/dL) as compared with G2 diabetic rats (199.6± 7.33 mg/dL). Data also revealed significant lower levels (p<0.05) of triglycerides, total cholesterol, LDL and VLDL and higher level of HDL cholesterol in diabetic rats treated with camel milk as compared with diabetic rats fed a normal diet. Conclusion: Raw camel milk improved the glycemic and lipid profile in diabetic rats. These findings indicate that raw camel milk may have potential benefits in the treatment of diabetes. Future studies will be needed to establish its safety and mechanism of action.