X-ray photoemission studies of the interaction of metals and metal ions with DNA

Author:

Mishra Esha1,Majumder Subrata2,Varma Shikha34,Dowben Peter A.1

Affiliation:

1. Department of Physics and Astronomy , University of Nebraska–Lincoln , Jorgenson Hall, 855 North 16th Street , Lincoln , NE 68588-0299 , USA

2. Department of Physics , National Institute of Technology , Patna , Bihar 800005 , India

3. Institute of Physics , Sachivalaya Marg , Bhubaneswar 751005 , India

4. Homi Bhabha National Institute , Training School Complex, Anushakti Nagar , Mumbai 400085 , India

Abstract

Abstract X-ray Photoelectron Spectroscopy (XPS) has been used to study the interactions of heavy metal ions with DNA with some success. Surface sensitivity and selectivity of XPS are advantageous for identifying and characterizing the chemical and elemental structure of the DNA to metal interaction. This review summarizes the status of what amounts to a large part of the photoemission investigations of biomolecule interactions with metals and offers insight into the mechanism for heavy metal-bio interface interactions. Specifically, it is seen that metal interaction with DNA results in conformational changes in the DNA structure.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

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