Synthetic methodologies to access bioactive bis-coumarin scaffold: a recent progress
Author:
Bedi Pooja1, Chaudhary Diksha2, Bose Reshmi3, Santra Soumava2, Ansari Kashif R.45, Kaur Rajbir3, Pramanik Tanay3, Sangtam Therola6, Singh Ambrish6
Affiliation:
1. Department of Chemistry , SGGS Khalsa College , Mahilpur 146105 , Punjab , India 2. Department of Chemistry, School of Chemical Engineering and Physical Sciences , Lovely Professional University , Phagwara 144411 , Punjab , India 3. Department of Chemistry , University of Engineering and Management , University Area, Action Area III, B/5, Newtown , Kolkata 700160 , West Bengal , India 4. School of New Energy and Materials , Southwest Petroleum University , Chengdu 610500 , Sichuan , P.R. China 5. State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation , Southwest Petroleum University , Chengdu 610500 , Sichuan , P.R. China 6. Department of Chemistry , Nagaland University , Lumami, Zunheboto 798627 , Nagaland , India
Abstract
Abstract
Heterocyclics particularly those containing oxygen and nitrogen atoms are unique precursors for the synthesis of various agrochemicals and pharmaceuticals. Bis-coumarins are well-known oxygen-containing heterocycles of great significance. The development of methods to prepare bis-coumarins is of great interest in synthetic organic chemistry because of their versatile importance in medicinal chemistry and chemical biology. Bis-coumarins are well known for their antibiotic, antimicrobial, anti-HIV, and antitumor activity. Due to the vast application of bis-coumarins, the synthesis of these heterocycles has attracted huge interest from researchers. In this review, we have summarized the diverse synthetic routes of bis-coumarin synthesis making use of different catalysts and solvents under versatile reaction conditions.
Publisher
Walter de Gruyter GmbH
Subject
Physical and Theoretical Chemistry
Reference113 articles.
1. Martins, M. A. P., Frizzo, C. P., Moreira, D. N., Buriol, L., Machado, P. Chem. Rev. 2009, 109, 4140–4182; https://doi.org/10.1021/cr9001098. 2. Stefanachi, A., Leonetti, F., Pisani, L., Farmaco, F., Moro, A., Orabona, E., Bari, I. Molecules 2018, 23, 1–34; https://doi.org/10.3390/molecules23020250. 3. Zhou, H., Dong, F., Du, X., Zhou, Z., Huo, H., Wang, W., Zhan, H., Dai, Y., Sui, Y., Li, J., Sui, F., Zhai, Y. H. Bioorg. Med. Chem. Lett. 2016, 26, 3876–3880; https://doi.org/10.1016/j.bmcl.2016.07.023. 4. Manolov, I., Maichle-moessmer, C., Nicolova, I., Danchev, N. Arch. Pharm. Chem. Life Sci. 2006, 339, 319–326; https://doi.org/10.1002/ardp.200500149. 5. Jung, J., Park, O. Molecules 2009, 14, 4790–4803; https://doi.org/10.3390/molecules14114790.
|
|