A novel near-infrared fluorescent probe for cysteine and application in bioimaging
Author:
Gu Xin12, Chen Jiajia2, Yang Xindi2, Zhou Wei1, Yang Li2
Affiliation:
1. College of Nursing and Health, Henan University , Kaifeng , Henan , 475004 , P. R. China 2. Henan Engineering Research Center of Industrial Recirculating Water Treatment, College of Chemistry and Molecular Sciences, Henan University , Kaifeng , Henan , 475004 , P. R. China
Abstract
Abstract
Cysteine (Cys) plays key roles in various pathological and physiological processes. Thus, the specific detection of Cys is a great necessity for the related disease diagnosis. Herein, we present a novel fluorescent probe based on a 2-benzothiazolyl-6-quinazolinyl-4-methylphenol moiety as fluorophore and a 2,4-dinitrobenzenesulfonyl moiety as detection functioned group. The probe presented a rapid and specific turn on response to Cys under physiological conditions, which could be convenient observed by the naked eyes. The detection mechanism was elucidated by HRMS, UV/vis absorption, fluorescence and DFT calculation. Furthermore, the probe was applied to monitor the endogenous Cys in living cells and mice.
Publisher
Walter de Gruyter GmbH
Subject
Physical and Theoretical Chemistry
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