New pathway in rheumatic mitral valve disease: cytochrome P450 and glutathione S transferase isozyme expression-Reference-Cited by-同舟云学术

New pathway in rheumatic mitral valve disease: cytochrome P450 and glutathione S transferase isozyme expression

Published:2020-04-02 Issue:6 Volume:45 Page:869-875
ISSN:1303-829X
Container-title:Turkish Journal of Biochemistry
language:en
Short-container-title:

Author:

Simsek Erdal¹^ORCID,Simsek Gulcin²,Soyal Mehmet Fazıl Tolga³,Kaygin Pinar⁴,Duzgun Ali Cemal⁵,Sarialtin Sezen⁶,Kaplan Sadi⁷,Oguztuzun Serpil⁴

Affiliation:

1. University of Health Sciences, Turkiye Yuksek Ihtisas Training and Research Hospital , Department of Cardiovascular Surgery , Ceyhun Atıf Kansu Street 166/4 Balgat , Ankara , Turkey , GSM: +90 532 328 02 17

2. University of Health Sciences, Kecioren Training and Research Hospital , Department of Pathology , Ankara , Turkey

3. Atilim University Faculty of Medicine Medicana International Ankara Hospital , Department of Cardiovascular Surgery Ankara , Ankara , Turkey

4. Kirikkale University, Faculty of Arts and Sciences , Department of Biology , Kirikkale , Turkey

5. University of Health Sciences Ankara Training and Research Hospital , Department of Cardiovascular Surgery , Ankara , Turkey

6. Ankara University, Faculty of Pharmacy , Department of Toxicology , Ankara , Turkey

7. University of Health Sciences, Turkiye Yuksek Ihtisas Training and Research Hospital , Department of Cardiovascular Surgery , Ankara , Turkey

Abstract

Abstract Objective Cytochrome P450 (CYP)1A1, glutathione S-transferase pi (GSTP1) and omega (GSTO1) isozymes were evaluated and compared in patients with the diagnosis of rheumatic mitral valve disease and ischemic mitral valve insufficiency to find out the relationship of the oxidative stress with rheumatic mitral valve disease. Materials and methods The control group consisted of patients operated on due to ischemic mitral valve insufficiency (group I, n:14) while study group consisted of the patients operated on with the diagnosis of rheumatic mitral valve disease (group II, n:29). Mitral valve materials were stained with hematoxylin and eosin. CYP1A1, GSTP1, and GSTO1 immunohistochemical markers were studied. Results 20.7% of GSTP1 isozyme protein expression was seen in the study group; however, no expression was detected in the control group. This finding was statistically significant in terms of GSTP1 isozyme. No statistically significant differences in the level of GSTO1 and CYP1A1 protein expression between the study and control groups were observed. Conclusion In this study, we found out that GSTP1 isozyme may be related to rheumatic mitral valve disease. A strategy that would help prevent oxidative stress in patients with rheumatic mitral valve disease can be a so valuable means to affect disease progression.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry, medical,Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/tjb-2019-0302/pdf

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