Cytotoxic constituents of Alocasia macrorrhiza-Reference-Cited by-同舟云学术

Cytotoxic constituents of Alocasia macrorrhiza

Published:2016-08-08 Issue:1-2 Volume:72 Page:21-25
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Elsbaey Marwa¹,Ahmed Kadria F.M.²,Elsebai Mahmoud F.²,Zaghloul Ahmed²³,Amer Mohamed M.A.²,Lahloub Mohamed-Farid I.²

Affiliation:

1. Pharmacognosy Department , Faculty of Pharmacy, Mansoura University , Mansoura 35516 , Egypt , Phone: +00201005437480, Fax: +02(050)2213101

2. Pharmacognosy Department , Faculty of Pharmacy, Mansoura University , Mansoura 35516 , Egypt

3. Pharmacognosy Department , Faculty of Pharmacy, Salman Bin Abdulaziz University , Riyadh 11451 , Saudi Arabia

Abstract

Abstract An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), β-sitosterol (9) and β-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50 of about 10 µM against Hep-2 larynx cancer cells).

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2015-0157/pdf

Reference25 articles.

1. Bailey LH. Manual of cultivated plants most commonly grown in the continental United States and Canada, 5th ed. New York: Macmillan Publishing Co, 1975:177.

2. Tyler VE, Brady LB, Robbers JE. Pharmacognosy, 7th ed. Philadelphia: Lea & Febiger, 1976:474.

3. Sambamurty AV. Taxonomy of angiosperms. New Delhi: I. K. International Pvt. Ltd, 2005:593.

4. Patil BR, Bamane SH, Khadsare UR. In-vitro protection of hepatocytes by Alocasia macrorrhiza leaf juice against CCl4 and tylenol mediated hepatic injury. Int J Pharmaceut App 2012;2:122–7.

5. Mubeen US, Vimlesh M, Santanu B. Laxative and diuretic property of ethanolic extract of the leaves of Alocasia macrorrhiza Linn. on experimental albino rats. Int Res J Pharm 2012;3:174–6.

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antiproliferative piperidine alkaloids from the leaves of Alocasia macrorrhiza;Phytochemistry;2024-06

2. Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza);Industrial Crops and Products;2024-04

3. Importance of Underground Storage Organs in Plants (for Their Survival and Perpetuation and for Human Welfare);Reference Series in Phytochemistry;2024

4. Protease inhibitors characterisation by SDS-PAGE and MALDI-TOF from Alocasia macrorrhizos and their modulation of macrophage immune-inflammatory properties;Natural Product Research;2023-08-24

5. Alocasia Odora Extract as Environmentally Benign Corrosion Inhibitor for Aluminum in HCl;MOROC J CHEM;2023