Isolation, antimicrobial and antitumor activities of a new polyhydroxysteroid and a new diterpenoid from the soft coral Xenia umbellata-Reference-Cited by-同舟云学术

Isolation, antimicrobial and antitumor activities of a new polyhydroxysteroid and a new diterpenoid from the soft coral Xenia umbellata

Published:2016-09-14 Issue:1-2 Volume:72 Page:27-34
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Ayyad Seif-Eldin N.¹²,Alarif Walied M.³,Al-Footy Khalid O.¹,Selim Elham A.¹,Ghandourah Mohamed A.³,Aly Magda M.⁴,Alorfi Hajer S.¹

Affiliation:

1. Department of Chemistry , Faculty of Science, King Abdulaziz University , P.O. Box 80203 , Jeddah 21589 , Saudi Arabia

2. Department of Chemistry , Faculty of Science, Damietta University , Damietta , Egypt

3. Department of Marine Chemistry , Faculty of Marine Sciences, King Abdulaziz University , P.O. Box 80207 , Jeddah 21589 , Saudi Arabia

4. Department of Biology , Faculty of Science, King Abdulaziz University , P.O. Box 80203 , Jeddah 21589 , Saudi Arabia

Abstract

Abstract A new C-30 steroid, 3β-,5α-,6β-,11α-,20β-pentahydroxygorgosterol (1), and a new diterpenoid, xeniumbellal (2), along with three known aromadendrane-type sesquiterpenes, aromadendrene (3), palustrol (4) and viridiflorol (5), were isolated from the soft coral Xenia umbellata. Chemical structures were determined by analyzing their NMR and MS data. The antimicrobial and antitumor activities of the isolated compounds were examined. Both 1 and 2 showed moderate antibacterial activities, especially against the multidrug-resistant Acinetobacter baumannii (MIC 0.22 and 0.28 mM, respectively); while 2 showed antitumor activity against a lymphoma cell line with LD50 0.57 mM and was nontoxic to Artemia salina at all tested concentrations up to about 4 mM.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2015-0228/pdf

Reference24 articles.

1. Schwartsmann G, Brondani da Rocha A, Berlinck RG, Jimeno J. Marine organisms as a source of new anticancer agents. Lancet Oncol 2001;2:221–5.

2. Coll JC. The chemistry and chemical ecology of octocorals (Coelenterata, Anthozoa, Octocorallia). Chem Rev 1992;92:613–31.

3. Bishara A, Rudi A, Goldberg I, Benayahu Y, Kashman Y. Novaxenicins A–D and xeniolides I–K, seven new diterpenes from the soft coral Xenia novaebrittanniae. Tetrahedron 2006;62:12092–7.

4. Munro MH, Blunt JW. Marine literature database. New Zealand: Department of Chemistry, University of Canterbury, 2006.

5. El-Gamal AA, Wang S-K, Duh C-Y. Xenibellal, a novel norditerpenoid from the Formosan soft coral Xenia umbellate. Tetrahedron Lett 2005;46:4499–500.

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