Two new alkylresorcinol derivatives from the leaves of Scyphocephalium ochocoa

Author:

Foundikou Hibrahim1,Mbiantcha Marius2,Bankeu Kezetas Jean-jules3,Tchouankeu Jean Claude4,Shaheen Farzana5,Choudhary Muhammad Iqbal5,Lebibi Jacques1,Feuya Tchouya Guy Raymond6

Affiliation:

1. Department of Chemistry, Faculty of Science , Université des Sciences et Techniques de Masuku , Box. 943 , Franceville , Gabon

2. Department of Animal Biology, Faculty of Sciences , University of Dschang , Box. 67 , Dschang , Cameroon

3. Department of Chemistry, Faculty of Science , University of Bamenda , Box. 39 , Bambili , Cameroon

4. Department of Organic Chemistry, Faculty of Science , University of Yaoundé 1 , Box. 812 , Yaoundé , Cameroon

5. International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry , University of Karachi , Karachi-75270 , Pakistan

6. Department of Chemistry, Faculty of Science , Université des Sciences et Techniques de Masuku , Box. 943 , Franceville , Gabon , Tel.: +241 06043682/07622381, Fax: +241 01677578

Abstract

Abstract Two new alkylresorcinol derivatives, namely ochocinone A and ochocinone B (1, 2), as well as a known alkylresorcinol oleiferinone (3) were isolated from the methanol extract of the leaves of Scyphocephalium ochocoa. The structures of these compounds were established by detailed spectroscopic analysis and by comparison with the spectral data of related known compounds. Compounds 1–3 showed significant immunomodulatory activity and cytotoxic effect on the mammary carcinoma MCF-7 cell line.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Reference40 articles.

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2. A. R. Walker, R. Sillans, in Les plantes utiles du Gabon (Ed.: P. Lechevalier), Sépia, Paris, 1961.

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4. M. Ahmed, J. Almas, A. H. Sobia, B. Afshan, A. K. Shukralla, A. Muhammad, F. Beenish, U. H. Zaheer, M. C. Iqbal, Chem. Biol. Drug. Des.2012, 79, 290.

5. J. Arnhold, Biochemistry2004, 69, 4.

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