New antifungal prenylated flavanones from Colutea armata
Author:
Inamullah Farah1, Fatima Itrat2, Khan Sadia1, Kazmi Mehdi Hassan1, Malik Abdul3, Afaq Shagufta1, Ali Muhammad Shaiq2, Farhad Zahid1, Tareen Rasool Bakhsh4, Abbas Tanveer5
Affiliation:
1. Department of Applied Chemistry , University of Karachi , Karachi-75270 , Pakistan 2. International Centre for Chemical and Biological Sciences (ICCBS) , University of Karachi , Karachi-75270 , Pakistan 3. International Centre for Chemical and Biological Sciences (ICCBS) , University of Karachi , Karachi-75270 , Pakistan , e-mail: 4. Department of Botany , Balochistan University , Sariab Road-87550 , Quetta , Pakistan 5. Department of Microbiology , University of Karachi , Karachi-75270 , Pakistan
Abstract
Abstract
Colucons A (1) and B (2), new prenylated flavanones, isolated from the EtOAc-soluble sub-fraction of the whole plant of Colutea armata Hemsl. & Lace along with four known compounds, namely, kenusanone J (3), hesperetin (4), tyrosol (5) and syringaldehyde (6), were reported for the first time from the species armata. Their structures were elucidated by spectroscopic techniques including 1H and 13C NMR (distortionless enhancement by polarization transfer), and 2D NMR experiments. Compounds 1–3 showed significant antifungal activity against Pseudallescheria boydii, Aspergillus niger, Trichophyton mentagrophytes, Macrophomina phaseolina and Candida glabrata, while compound 4 showed moderate antifungal activity.
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
Reference12 articles.
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