Affiliation:
1. Beijing Advanced Innovation Center for Soft Matter Science and Engineering , State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing Laboratory of Biomedical Materials , Beijing University of Chemical Technology , Beijing , China
Abstract
Abstract
Metal ions are widely present in biological systems and participate in many critical biochemical processes such as material transportation, energy conversion, information transmission and metabolic regulation, making them indispensable substance in our body. They can cause health problems when deficiency or excess occurs. To understand various metabolic processes and facilitate diseases diagnosis, it is very important to measure the content and monitor the distribution of metal ions in individual cells, tissues and whole organisms. Among the various methods for metal ion detection, fluorescent sensors with organic dyes have attracted tremendous attention due to many advantages such as high fluorescence quantum yield, facile modification approaches and biocompatibility in addition to operation ease, high sensitivity, fast detection speed, and real-time detection. This review summarizes the recent progress on the detection and imaging of the metal ions in biological systems including Na+, K+, Ca2+, Mg2+, Fe2+/Fe3+, Zn2+, and Cu2+ provides an opinion on remaining challenges to be addressed in this field.
Reference116 articles.
1. Carter KP, Young AM, Palmer AE. Fluorescent Sensors for Measuring Metal Ions in Living Systems. Chem Rev. 2014;114:4564–601.
2. Weaver CM. Calcium. In Present Knowledge in Nutrition; 10th Ed. Erdman Jr. JW, Macdonald IA, Zeisel SH, Ed. Wiley-Blackwell, 2012.
3. Rude RK. Magnesium. In Encyclopedia of Dietary Supplements; 2nd Ed. Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, et al., Ed. CRC Press: New York, 2010.
4. Aggett PJ. Iron. In Present Knowledge in Nutrition; 10th Ed. Erdman Jr. JW, Macdonald IA, Zeisel SH, Ed. Wiley-Blackwell, 2012.
5. Nielsen F. Ultratrace minerals. In Modern Nutrition in Health and Disease; 11th Ed. Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, Ed. Williams and Wilkins: Baltimore, 1999.
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