Affiliation:
1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel
Abstract
AbstractContact sites, areas where two organelles are held in close proximity through the action of molecular tethers, enable non-vesicular communication between compartments. Mitochondria have been center stage in the contact site field since the discovery of the first contact between mitochondria and the endoplasmic reticulum (ER) over 60 years ago. However, only now, in the last decade, has there been a burst of discoveries regarding contact site biology in general and mitochondrial contacts specifically. The number and types of characterized contacts increased dramatically, new molecular mechanisms enabling contact formation were discovered, additional unexpected functions for contacts were shown, and their roles in cellular and organismal physiology were emphasized. Here, we focus on mitochondria as we highlight the most recent developments, future goals and unresolved questions in the field.
Funder
Deutsche Forschungsgemeinschaft
H2020 European Research Council
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Reference282 articles.
1. The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseases;Cold Spring Harb. Perspect. Biol.,2013
2. Endosome-mitochondria interactions are modulated by iron release from transferrin;J. Cell. Biol.,2016
3. Close topographical relationship between mitochondria and ergastoplasm of liver cells in a definite phase of cellular activity;J. Biophys. Biochem. Cytol.,1956
4. [Submicroscopical structure of cytoplasmic basophils in the liver, pancreas and salivary gland; study of ultrafine slices by electron microscope];Z. Zellforsch Mikrosk Anat.,1952
5. The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation;J. Clin. Invest.,2012
Cited by
32 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献