Highly efficient [3+3] cycloaddition reactions of in situ generated aza-oxyallyl cation with nitrones

Abstract

AbstractAn efficient protocol was developed for the synthesis of 1,2,4-oxadiazinan-5-one derivatives via [3+3] cycloaddition ofin situgenerated aza-oxyallyl cations with nitrones. This method provides high yields of the heterocyclic products, excellent regioselectivity and broad substrate scope.