Convenient Synthesis and Evaluation of Biological Activity of Benzyl (2S)-2-[(R)-1-hydroxy-2-oxo-(1-phenethyl)prop-3-ylcarbamoyl]- 4-oxopiperidine- (or -4-oxopyrrolidine)-1-carboxylate as Novel Histone Deacetylase Inhibitors-Reference-Cited by-同舟云学术

Convenient Synthesis and Evaluation of Biological Activity of Benzyl (2S)-2-[(R)-1-hydroxy-2-oxo-(1-phenethyl)prop-3-ylcarbamoyl]- 4-oxopiperidine- (or -4-oxopyrrolidine)-1-carboxylate as Novel Histone Deacetylase Inhibitors

Published:2008-11-01 Issue:11 Volume:63 Page:1300-1304
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Oh Seikwan¹,Moon Hyung-In²,Jung Jae-Chul¹,Avery Mitchell A.³

Affiliation:

1. Department of Neuroscience and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea

2. Department of Neuroscience and Inam Neuro Science Research Center, Wonkwang University Sanbon Medical Center, Sanbondong, Gunpocity, Kyunggido, 435-040, South Korea

3. Department of Medicinal Chemistry, School of Pharmacy, National Center for Natural Products Research & Department of Chemistry, University of Mississippi, University, MS 38677-1848, USA

Abstract

Abstract A simple synthesis, involving a key coupling reaction, and the biological activity of the title compounds 16 and 17 are described. The key fragments are the amine·HCl salt 6 and the acids 9 and 13, which were smoothly coupled by using ethyl(dimethylaminopropyl)carbodiimide (EDCI) and 1- hydroxybenzotriazole (HOBt) in high yield.We have found that the in vitro growth inhibitory potency of the new compounds 16 and 17 exhibits good histone deacetylase (HDAC) activity.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2008-1108/pdf

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