Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and adolescents-Reference-Cited by-同舟云学术

Definition of reference ranges for β-isomerized carboxy-terminal telopeptide collagen type I for children and adolescents

Published:2018-05-11 Issue:6 Volume:31 Page:637-640
ISSN:2191-0251
Container-title:Journal of Pediatric Endocrinology and Metabolism
language:en
Short-container-title:

Author:

de Melo Veronica C.P.¹,Ferreira Paulo R.S.¹,Ricardi Lucelia O.¹,Batista Marcelo C.¹,França Carolina N.²,Ferreira Carlos E. dos S.¹³

Affiliation:

1. Hospital Israelita Albert Einstein , São Paulo, SP , Brazil

2. Universidade Santo Amaro , Pós Graduação em Ciências da Saúde , São Paulo, SP , Brazil

3. Federal University of São Paulo , São Paulo, SP , Brazil

Abstract

Abstract Background: Bone metabolism involves many complex pathways that are disturbed by several bone diseases. The literature shows some limitations concerning pediatric reference intervals to bone markers, mainly because of the low number of patients included in the studies, the heterogeneity of methods, beyond the fact that it is time-consuming and expensive. The aim of this study was to determine reference values for β-isomerized carboxy-terminal telopeptides collagen type I (β-CTX), a marker of bone resorption, for children and adolescents. Methods: Blood samples from 246 patients were collected and β-CTX was measured using an electrochemiluminescence immunoassay (ECLI). Results and conclusions: We propose reference ranges for β-CTX concentration from the 2.5 percentile and 97.5 percentile for each age group. The reference values obtained, concerning children and adolescents, might be useful in the evaluation of diseases such as osteosarcoma and anorexia in both childhood as adolescence.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpem-2018-0005/pdf

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