Associations between IGF-I, IGF-binding proteins and bone turnover markers in prepubertal obese children-Reference-Cited by-同舟云学术

Associations between IGF-I, IGF-binding proteins and bone turnover markers in prepubertal obese children

Published:2015-01-01 Issue:5-6 Volume:28 Page:
ISSN:2191-0251
Container-title:Journal of Pediatric Endocrinology and Metabolism
language:
Short-container-title:

Author:

Gajewska Joanna,Klemarczyk Witold,Ambroszkiewicz Jadwiga,Szamotulska Katarzyna,Chełchowska Magdalena,Weker Halina

Abstract

Abstract: To assess the relationships between components of the growth hormone axis, body composition, and bone markers in obese children.: We determined the levels of bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), insulin-like growth factor-I (IGF-I), and IGF-binding proteins (IGFBPs) by immunoenzymatic methods, and body composition by dual-energy X-ray absorptiometry in 45 obese and 20 non-obese children.IGF-I and functional IGFBP-3 levels, IGF-I/total IGFBP-3, and functional IGFBP-3/total IGFBP-3 molar ratios were significantly higher in obese patients than in controls. Multivariate regression analysis in obese patients showed significant associations of BALP with IGF-I (p=0.047) and percent of body fat mass (p=0.002).The relationship of IGF-I and functional IGFBP-3 to BALP may support the concept of IGF-I influence on accelerated bone formation process in obesity. Moreover, IGF-I and percentage of body fat mass may be significant predictors of BALP in obese during the prepubertal period.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health

Link

https://www.degruyter.com/document/doi/10.1515/jpem-2014-0326/pdf

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