Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature

Abstract

AbstractBackground:Fetal goitrous hypothyroidism is mainly caused by maternal treatment of Graves’ disease. Fetal goiter sometimes compresses the trachea and esophagus and may cause polyhydramnios, preterm labor, complications of labor and delivery, and neonatal respiratory disorder.Case presentation:We report a case of fetal goitrous hypothyroidism in which the mother had Graves’ disease, which was treated with propylthiouracil. Intra-amniotic levothyroxine (L-TConclusions:Previous reports on fetal goitrous hypothyroidism that was treated with intra-amniotic L-T