Evaluation of inflammatory and oxidative biomarkers in children with well-controlled congenital hypothyroidism

Abstract

AbstractTo investigate well-controlled congenital hypothyroidism on the markers associated with early kidney injury and oxidative DNA damage.Twenty-three children with euthyroid congenital hypothyroidism aged 3–6 years and 19 age- and gender-matched controls were enrolled. Serum levels of albumin, C-reactive protein, cysteine C, globulin, pre-albumin, and total protein were detected. Urine levels of albumin, fibrin degradation products, IgG, βSerum levels of C-reactive protein were higher, but pre-albumin was lower in patients with congenital hyperthyroidism compared with the controls (all p<0.001). Urinary levels of IgG were higher in patients with congenital hyperthyroidism than in the controls (p=0.011). However, urinary levels of albumin excretion and 8-OHdG were similar to those in the controls. Serum pre-albumin levels were negatively correlated with urinary 8-OHdG levels (r=−0.479, p=0.016) in patients with congenital hypothyroidism.It is concluded that inflammatory and oxidative markers were slightly altered in well-controlled congenital hypothyroidism. The levels of urinary 8-OHdG and albumin excretion were not significantly different.