Author:
Chen Yen-Chun,Chen Li-Min,Lin Hung-Hsun,Chen Bai-Hsiun,Chao Mei-Chyn,Hsiao Hui-Pin
Abstract
AbstractBackground:Central precocious puberty (CPP), predominant in girls, is defined by early development of secondary sexual characteristics driven by the early secretion of hypothalamic gonadotropin releasing hormone (GnRH) and subsequent gonadotropin. Recent studies have shown variation in theMethods:This study attempted to investigate the relation between single-nucleotide polymorphisms (SNPs) inResults:We found genotype frequencies in rs314276 and rs221634 were significantly correlated with girls with CPP; while the C allele frequency in rs314276 showed the dominant trait. Standard deviation score (SDS) of weight and body mass index (BMI) were higher in CC homozygotes of rs314276 in girls with CPP.Conclusions:Our results demonstrate that the genotype of rs314276 in
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology, and Child Health
Cited by
10 articles.
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