Elevated serum uric acid, hyperuricaemia and dietary patterns among adolescents in mainland China

Author:

Zhou Hang12,Ma Zheng Feei3,Lu Yiming14,Du Yanyan12,Shao Jian12,Wang Liya12,Wu Qin15,Pan Binyu6,Zhu Wenxi7,Zhao Qihua12,Wei Hua12

Affiliation:

1. Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China

2. Department of Clinical Nutrition, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu Province, China

3. Department of Health and Environmental Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu Province, China

4. Department of Orthopedics, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu Province, China

5. Department of Rheumatology and Immunology, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu Province, China

6. Department of Clinical Nutrition, The First People’s Hospital of Wujiang District, Suzhou, Jiangsu Province, China

7. Yangzhou Emergency Medical Center, Yangzhou, Jiangsu Province, China

Abstract

AbstractBackgroundElevated serum uric acid concentrations have been associated with metabolic syndrome. However, only limited information is available on the prevalence of hyperuricaemia in adolescents. Therefore, the aim of our cross-sectional study was to study the prevalence of hyperuricaemia and dietary patterns in adolescents aged 13–16 years living in Yangzhou, China.MethodsAdolescents were asked to complete a 20-item food frequency questionnaire (FFQ) and provide an overnight fasting finger-prick sample. Principal component analysis (PCA) with varimax rotation was used to derive the dietary patterns that might be associated with high uric acid concentrations.ResultsA total of 1070 adolescents were recruited. Of these, 53.6% (n = 574) were females, and 58.5% (n = 625) were within the normal body mass index (BMI) range. The males had a significantly higher serving size and frequency in their weekly food consumption, including meat, poultry, Chinese cereal staple foods and Western-style fast foods, than the females (all p < 0.02). The overall mean serum uric acid concentration and prevalence of hyperuricaemia were 368.6 ± 114.5 μmol/L and 37.9%, respectively. The prevalence of hyperuricaemia was 4.633 times greater among the participants who were overweight and obese than among those who were underweight. On the other hand, the prevalence of hyperuricaemia was 0.694 times lower among the participants who had normal weight than those who were underweight.ConclusionsThe prevalence of hyperuricaemia was relatively high in Chinese adolescents. The prevention of hyperuricaemia measures should be strengthened in adolescents to effectively control for obesity and gout, which tend to persist into adulthood.

Publisher

Walter de Gruyter GmbH

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Pediatrics, Perinatology and Child Health

Reference36 articles.

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