Beyond the classic extinction network: a wider, comparative view-Reference-Cited by-同舟云学术

Beyond the classic extinction network: a wider, comparative view

Published:2020-07-31 Issue:3 Volume:26 Page:161-169
ISSN:0947-0875
Container-title:Neuroforum
language:en
Short-container-title:

Author:

Güntürkün Onur¹^ORCID,Stüttgen Maik C.²^ORCID,Starosta Sarah³,Pusch Roland¹,Gao Meng¹,Nitsche Michael⁴,Ernst Thomas M.⁵,Ladd Mark E.⁶,Quick Harald H.⁷⁸,Timmann Dagmar⁵

Affiliation:

1. Department of Biopsychology, Faculty for Psychology , Ruhr University Bochum , 44780 Bochum , Germany

2. Institute of Pathophysiology , University Medical Center of the Johannes Gutenberg University , Mainz , Germany

3. Department of Neuroscience , Washington University St. Louis , St. Louis , MO 63110 , USA

4. Department of Psychology and Neurosciences , Leibniz Research Centre for Working Environment and Human Factors , Ardeystr. 67 , 44139 Dortmund , Germany

5. Department of Neurology , Essen University Hospital, University of Duisburg Essen , 45147 Essen , Germany

6. Division of Medical Physics in Radiology , German Cancer Research Center , 69120 Heidelberg , Germany

7. Erwin L. Hahn Institute for Magnetic Resonance Imaging , University of Duisburg-Essen , 45141 Essen , Germany

8. High-Field and Hybrid MR Imaging , Essen University Hospital , 45147 Essen , Germany

Abstract

Abstract Extinction learning modifies the dynamics of brain circuits such that a previously learned conditioned response is no longer generated. The majority of extinction studies use fear conditioning in rodents and identified the prefrontal cortex, the hippocampus, and the amygdala as core regions of the extinction circuit. We sought to find answers to two questions: First, do we find a similar functional brain circuit in birds, which underwent a 300-million-year separate evolution from mammals? Second, do we have to incorporate the cerebellum as a key component of the central extinction circuit? We indeed show that the avian extinction pathways are not identical but highly similar to those of mammals. In addition, we reveal that the human cerebellum processes prediction errors, a key element driving extinction of learned fear responses, and contributes to context-related effects of extinction.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Walter de Gruyter GmbH

Subject

Neurology (clinical),Neurology

Link

https://www.degruyter.com/document/doi/10.1515/nf-2020-0015/pdf

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