Bioactivity of Flavonoids Isolated from Lychnophora markgravii against Leishmania amazonensis Amastigotes-Reference-Cited by-同舟云学术

Bioactivity of Flavonoids Isolated from Lychnophora markgravii against Leishmania amazonensis Amastigotes

Published:2009-08-01 Issue:7-8 Volume:64 Page:509-512
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Salvador Marcos José¹,Sartori Fabiana Terezinha²,Sacilotto Ana Claudia B. C.²,Pral Elizabeth M. F.³,Alfieri Silvia Celina³,Vichnewski Walter²⁴

Affiliation:

1. Curso de Farmácia, Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6109, CEP 13083-970, Campinas (SP), Brazil

2. Departamento de Química, Faculdade de Filosofi a, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (USP), Avenida dos Bandeirantes, 14040-901, Ribeirão Preto (SP), Brazil

3. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo (USP), Avenida Professor Lineu Prestes, 1374, 05508-900, São Paulo (SP), Brazil

4. Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Avenida do Café s/n, 14040-903, Ribeirão Preto (SP), Brazil

Abstract

The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2009-7-807/pdf

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Propolis‐Derived Small Molecule Tectochrysin Ameliorates Type 2 Diabetes in Mice by Activating Insulin Receptor β;Molecular Nutrition & Food Research;2023-10-27

2. Screening of traditional medicinal plant extracts and compounds identifies a potent anti-leishmanial diarylheptanoid fromSiphonochilus aethiopicus;Journal of Biomolecular Structure and Dynamics;2023-05-18

3. Ethnopharmacological Uses, Pharmacological Activities, and Therapeutic Applications of Tectochrysin in Medicine: An Important Class of Dietary Flavonoid;Cardiovascular & Hematological Disorders-Drug Targets;2023-03

4. Current advances on the therapeutic potential of pinocembrin: An updated review;Biomedicine & Pharmacotherapy;2023-01

5. Tectochrysin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology;Handbook of Dietary Flavonoids;2023