Antimalarial Compounds from the Stem Bark of Vismia laurentii-Reference-Cited by-同舟云学术

Antimalarial Compounds from the Stem Bark of Vismia laurentii

Published:2009-04-01 Issue:3-4 Volume:64 Page:210-214
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Noungoue Diderot T.¹,Chaabi Mehdi²,Ngouela Silvère¹,Antheaume Cyril³,Boyom Fabrice F.⁴,Gut Jiri⁵,Rosenthal Philip J.⁵,Lobstein Annelise²,Tsamo Etienne¹

Affiliation:

1. Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon

2. Laboratory of Pharmacognosy, LC1 UMR 7175, ULP, Faculty of Pharmacy, Strasbourg, France

3. Laboratory of NMR, LC1 IFR85, ULP, Faculty of Pharmacy, Strasbourg, France

4. Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon

5. Division of Infectious Diseases Department of Medicine, University of California, San Francisco, CA 94943, USA

Abstract

A phytochemical study of the stem bark of Vismia laurentii resulted in the isolation of a tetracyclic triterpene, tirucalla-7,24-dien-3-one (1), and seven other known compounds: 3-geranyloxyemodin (2), vismiaquinone A (3), vismiaquinone B (4), bivismiaquinone (5), epifriedelinol (6), betulinic acid (7) and stigmasta-7,22-dien-3-ol (8). The structure of all these compounds was elucidated by spectroscopic means. The stem bark extract and compounds 1 and 3 showed good antimalarial activity against the W2 strain of Plasmodium falciparum.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2009-3-410/pdf

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