New Naphthoquinone Derivatives from the Ascomycete IBWF79B-90A-Reference-Cited by-同舟云学术

New Naphthoquinone Derivatives from the Ascomycete IBWF79B-90A

Published:2009-06-01 Issue:1-2 Volume:64 Page:25-31
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Schüffler Anja¹,Liermann Johannes C.²,Kolshorn Heinz³,Opatz Till²,Anke Heidrun⁴

Affiliation:

1. University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany

2. Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany

3. Institute of Organic Chemistry, University of Mainz, Duesbergweg 10 – 14, D-55128 Mainz, Germany

4. Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany

Abstract

Bioactivity-guided fractionation of extracts from the fungus IBWF79B-90A resulted in the isolation of three known naphthoquinones, herbarin, dehydroherbarin, and O-methylherbarin and the azaanthraquinone scorpinone as well as three structurally related derivatives, O-phenethylherbarin and herbaridines A and B. All seven compounds exhibited cytotoxic activities against several cell lines.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2009-1-205/pdf

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