An application of continuous flow microreactor in the synthesis and extraction of rabeprazole-Reference-Cited by-同舟云学术

An application of continuous flow microreactor in the synthesis and extraction of rabeprazole

Published:2021-03-01 Issue:3 Volume:19 Page:287-294
ISSN:1542-6580
Container-title:International Journal of Chemical Reactor Engineering
language:en
Short-container-title:

Author:

Duan Zhenya¹,Wang Yan¹,Zhang Ling²,Cao Xing¹,Fu Lihua³,Li Zhenjiang⁴,Zhang Junmei⁵

Affiliation:

1. College of Electromechanical Engineering, Qingdao University of Science and Technology , Qingdao 266061 , Shandong Province , China

2. Shandong Xinhua Pharmaceutical Company Limited , Zibo 255000 , Shandong Province , China

3. Engineering Training Center, Shandong University of Technology , Zibo 255049 , Shandong Province , China

4. Chinesisch-Deutsche Technische fakultat, Qingdao University of Science and Technology , Qingdao 266061 , Shandong Province , China

5. College of Chemical Engineering, Qingdao University of Science and Technology , Qingdao 266042 , Shandong Province , China

Abstract

Abstract The oxidation of rabeprazole sulfide is a key step in the synthesis of rabeprazole, a drug for the treatment of stomach acid-related disorders. The current rabeprazole production process adopts one pot batch process, which has low reaction efficiency and poor stability. A continuous process can greatly improve the production efficiency and solve the above problems. Therefore, the reaction parameters of rabeprazole in microreactor were explored through laboratory experiments to explore the possibility of continuous production of rabeprazole. Rabeprazole sodium was synthesized by using rabeprazole thioether as a raw material and sodium hypochlorite solution as the oxidant. Oxidation, quenching, acid-base regulation and extraction were completed continuously in the microreactor. Rabeprazole solution with a purity of 98.78% (±0.13%) can be obtained continuously in 56 s, whereas intermittent production lasted for at least 2 h. Thus, the microreactor can effectively improve the oxidation synthesis efficiency of rabeprazole, and provide reference for the realization of other reactions in the microreactor.

Publisher

Walter de Gruyter GmbH

Subject

General Chemical Engineering

Reference30 articles.

1. Ashok, K., K. Ramdas, and P. Muniyan. 2009. “Process for Preparation of Pyridinylmethylsulphinyl Benzimidazole Compounds and Pyridine Intermediates.” WO Patent 2009116072A1.

2. Auttajaroon, J., R. K. Vilaichone, P. Chotivitayatarakorn, and V. Mahachai. 2019. “Once-daily Rabeprazole, Levofloxacin, Clarithromycin-MR, and Bismuth for Helicobacter pylori eradication: A Randomized Study of 7 or 14 Days (ONCE Study).” Helicobacter 24 (5). https://doi.org/10.1111/hel.12615.

3. Bensabath, T., M. D. Le, H. Monnier, and P. A. Glaude. 2019. “Polycyclic Aromatic Hydrocarbon (PAH) Formation during Acetylene Pyrolysis in Tubular Reactor under Low Pressure Carburizing Conditions.” Chemical Engineering and Science 202: 84–94. https://doi.org/10.1016/j.ces.2019.03.030.

4. Bourlon, S., G. Veyrac, C. Armand, O. Lambert, M. Bourin, and Jolliet. 2003. “P., Rhabdomyolysis during Treatment with Rabeprazole (Pariet (R)), a Proton Pump Inhibitor Associated with Domperidone (Peridys (R)).” Therapie 57 (6): 597–600.

5. Broeckx, R., M. Laurent, D. De Smaele, S. Leurs, and H. Marcel. 2002. “Improved Process for Preparing Benzimidazole Type Compounds.” WO Patent 03/008406A1.

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent advances in polyoxometalates based strategies for green synthesis of drugs;Chinese Chemical Letters;2024-04

2. Development of a Novel Multi-Phase Flow Reactor and Optimization of Mixing Effect Based on a Liquid-Liquid System;Theoretical Foundations of Chemical Engineering;2023-12

3. An O-Demethylation Metabolite of Rabeprazole Sulfide by Cunninghamella blakesleeana 3.970 Biotransformation;Catalysts;2022-12-22