An application of continuous flow microreactor in the synthesis and extraction of rabeprazole-Reference-Cited by-同舟云学术

An application of continuous flow microreactor in the synthesis and extraction of rabeprazole

Published:2021-03-01 Issue:3 Volume:19 Page:287-294
ISSN:1542-6580
Container-title:International Journal of Chemical Reactor Engineering
language:en
Short-container-title:

Author:

Duan Zhenya¹,Wang Yan¹,Zhang Ling²,Cao Xing¹,Fu Lihua³,Li Zhenjiang⁴,Zhang Junmei⁵

Affiliation:

1. College of Electromechanical Engineering, Qingdao University of Science and Technology , Qingdao 266061 , Shandong Province , China

2. Shandong Xinhua Pharmaceutical Company Limited , Zibo 255000 , Shandong Province , China

3. Engineering Training Center, Shandong University of Technology , Zibo 255049 , Shandong Province , China

4. Chinesisch-Deutsche Technische fakultat, Qingdao University of Science and Technology , Qingdao 266061 , Shandong Province , China

5. College of Chemical Engineering, Qingdao University of Science and Technology , Qingdao 266042 , Shandong Province , China

Abstract

Abstract The oxidation of rabeprazole sulfide is a key step in the synthesis of rabeprazole, a drug for the treatment of stomach acid-related disorders. The current rabeprazole production process adopts one pot batch process, which has low reaction efficiency and poor stability. A continuous process can greatly improve the production efficiency and solve the above problems. Therefore, the reaction parameters of rabeprazole in microreactor were explored through laboratory experiments to explore the possibility of continuous production of rabeprazole. Rabeprazole sodium was synthesized by using rabeprazole thioether as a raw material and sodium hypochlorite solution as the oxidant. Oxidation, quenching, acid-base regulation and extraction were completed continuously in the microreactor. Rabeprazole solution with a purity of 98.78% (±0.13%) can be obtained continuously in 56 s, whereas intermittent production lasted for at least 2 h. Thus, the microreactor can effectively improve the oxidation synthesis efficiency of rabeprazole, and provide reference for the realization of other reactions in the microreactor.

Publisher

Walter de Gruyter GmbH

Subject

General Chemical Engineering

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