Herkunftsbestimmung von Arzneimitteln durch Messung von natürlichen Isotopenverhältnissen: D/H und 13C/12C Verhältnisse einiger Proben von Diazepam / Determination of the Origin of Drugs by Measuring Natural Isotope Contents: D/H and 13C/12C Ratios of Some Diazepam Samples-Reference-Cited by-同舟云学术

Herkunftsbestimmung von Arzneimitteln durch Messung von natürlichen Isotopenverhältnissen: D/H und 13C/12C Verhältnisse einiger Proben von Diazepam / Determination of the Origin of Drugs by Measuring Natural Isotope Contents: D/H and 13C/12C Ratios of Some Diazepam Samples

Published:1976-04-01 Issue:3-4 Volume:31 Page:111-114
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Bommer Peter¹,Moser Heribert²,Stichler Willibald²,Trimborn Peter²,Vetter Walter¹

Affiliation:

1. Firma F. Hoffmann-La Roche & Co. AG, Basel

2. Institut für Radiohydrometrie, Gesellschaft für Strahlen-und Umweltforschung mbH, Neuherberg bei München

Abstract

Abstract The precise determination of the natural isotopic abundance ratios of carbon and hydrogen in several production batches of the commercial product 7-chlor-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-on (diazepam) gave results which allowed certain batches to be differentiated. The differences in the ratios appear to be mainly due to differences in the isotopic composition of the (fossile) starting materials of the synthesis. The measurement of the natural isotopic ratios may therefore offer another possibility to deter mine the origin of a drug.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-1976-3-401/pdf

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1. Forensic Applications of Isotope Ratio Mass Spectrometry;Mass Spectrometry Handbook;2012-05-21

2. Forensic applications of isotope ratio mass spectrometry—A review;Forensic Science International;2006-02

3. Determination of ‘common-batch’ members in a set of confiscated 3,4-(methylendioxy)-methylamphetamine samples by measuring the natural isotope abundances: a preliminary study;Forensic Science International;1995-02

4. Gas chromatography with mass spectrometry or isotope-ratio mass spectrometry in studying the geographical origin of heroin;Analytica Chimica Acta;1991-07

5. ISOTOPES AND FOOD;The Terrestrial Environment, B;1986