Author:
Foroumandi Elaheh,Alizadeh Mohammad,Kheirouri Sorayya
Abstract
Summary
Background: Glycative stress is involved in the pathogenesis of various degenerative disorders. This study sought to determine the effect of age-related changes in amino acids on serum levels of pentosidine and carboxymethyl-lysine (CML) in healthy individuals.
Methods: The subjects were 78 healthy individuals categorized into three age groups. The ages of the groups were as follows: 26 young adults (20–30 y, 25.2±3.03), 26 middle-aged adults (35–50 y, 39.46±6.97) and 26 older adults (60 y or older, 69.80±10.01). Serum levels of pentosidine and CML were measured by ELISA and levels of plasma amino acids were determined using HPLC.
Results: Serum levels of pentosidine and CML in the youngest group were higher than in the oldest group (p=0.026, 0.029, respectively). There was a positive correlation between the serum levels of pentosidine and CML and the levels of plasmaTyrosine (p=0.032, r=0.211 and p=0.037, r=0.224), Valine (p=0.037, r=0.224 and p=0.021, r=0.247) and Isoleucine (p=0.041, r=0.203 and p=0.021, r=0.247), respectively. Serum levels of pentosidine and CML may be modulated by the plasma levels of selected amino acids.
Conclusions: Better understanding of the role of these selective amino acids might provide new perception of how glycation pathways may be altered and pave the way for new therapeutic principles.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference74 articles.
1. Advanced glycation end - products pentosidine and carboxymethyllysine are elevated in serum of patients with osteoporosis;Hein;Rheumatology,2003
2. assessment by anti medical checkup;Yonei;Aging aging Proceedings
3. is no longer an unsolved problem in biology of the New;Holliday;Aging Annals York Academy of Sciences,2006
4. of the adult human plasma metabolome Future;Lawton;Analysis Medicine,2008
5. Nagano Effect of age and menopause on serum concentrations of pentosidine an advanced glycation end product The A and;Takahashi;Journals of Gerontology Series Biological Sciences Medical Sciences,2000
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