Computational study of intravenous magnetic drug targeting using implanted magnetizable stent
Author:
Krafcik Andrej1ORCID, Babincova Melania2ORCID, Babinec Peter2ORCID, Frollo Ivan1ORCID
Affiliation:
1. Institute of Measurement Science, Slovak Academy of Sciences , Dubravska Cesta 9, 841 04 Bratislava , Slovakia 2. Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics , Comenius University , Mlynska Dolina F1, 842 48 Bratislava , Slovakia
Abstract
Abstract
Magnetic carriers for guiding, delivery, and capturing of drugs to desired place attract interest in the field of smart treatment of various pathological conditions. Presented paper, therefore, deals with one such application with the theoretical model of magnetic fluid flow through vessel bifurcation with one arm treated with ferromagnetic vascular stent placed in an external originally homogeneous magnetic field. This flow was described as laminar Newtonian incompressible continuum of the magnetic many-bead system, with Reynolds number
≈
1
$\approx 1$
, using magnetic force variant of the Nernst–Planck equation coupled with the Navier–Stokes equations, solved numerically by the finite element method (FEM). This approach allowed us to quantify capturing efficiency of magnetic beads in each arm of bifurcation vessels. Results show reduction of the number of magnetic beads entering as well as leaving the arm treated with stent in comparison with the untreated one. For stented bifurcation arm, the significant amount of beads are captured to its luminal surface, which may be used for drug delivery using magnetic carriers.
Funder
Slovak Scientific Grant Agency Slovak Research and Development Agency
Publisher
Walter de Gruyter GmbH
Subject
Applied Mathematics,General Physics and Astronomy,Mechanics of Materials,Engineering (miscellaneous),Modeling and Simulation,Computational Mechanics,Statistical and Nonlinear Physics
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