Affiliation:
1. Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Department of Medical Biology
2. Clinic of Surgery and Transplant Center
3. ZILPO, s.r.o., Žilina
Abstract
Abstract
This review article is concentrating on the news in the pathophysiology of chronic venous insufficiency (CVD). Despite ongoing progress in understanding the molecular aspects of CVD the exact mechanism of its development remains unclear. Many different factors may play role in the pathogenesis of CVD, including changes in hydrostatic pressure, valvular incompetence, increased capillary permeability, endothelial dysfunction, activation of leukocytes, deep venous obstruction, capillary microthrombosis, ineffective function of calf muscle pump, biochemical and structural changes in the vessel wall, extracellular matrix alteration, and several other mechanisms. A better understanding of the pathophysiology is an important step in the finding of new potential treatment.
Subject
General Biochemistry, Genetics and Molecular Biology,General Nursing
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