Megistolactone, a New Alkaloid from Sarcomelicope megistophylla

Author:

Fokialakis Nikolas1,Magiatis Prokopios1,Skaltsounis Alexios-Leandros1,Tillequin François2,Sévenet Thierry3

Affiliation:

1. Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens Panepistimiopolis Zografou, GR-15771 Athens, Greece.

2. Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens Panepistimiopolis Zografou, GR-15771 Athens, Greece. Laboratoire de Pharmacognosie de TUniversite Rene Descartes, UMR/CNRS No 8638,

3. Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens Panepistimiopolis Zografou, GR-15771 Athens, Greece. ICSN du CNRS. F-91190 Gif-sur-Yvette, France

Abstract

A new quinolone alkaloid, megistolactone (1) was isolated from the bark of Sarcomelicope megistophylla. Its structure has been elucidated on the basis of MS and NMR data. From a biogenetic point of view, this compound should be considered as an oxidation product of 1,2,3,4-tetra-O-subsituted acridone alkaloids, which are also present in the bark.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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