Two Antinematodal Phenolics from Knema hookeriana, a Sumatran Rainforest Plant

Author:

Alen Yohannes1,Nakajima Shuhei2,Nitoda Teruhiko3,Baba Naomichi2,Kanzaki Hiroshi2,Kawazu Kazuyoshi3

Affiliation:

1. The Graduate School of Natural Science and Technology, Department of Applied Bioscience and Biotechnology, Laboratory of Natural Products Chemistry, Okayama University, Tsushima naka 3-1-1, Okayama 700-8530, Japan. / Faculty of Agriculture, Okayama University, Tsushima naka 1-1-1, Okayama 700-8530, Japan / On Leave from Laboratory of Natural Products Chemistry Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Andalas University, Padang, Indonesia

2. The Graduate School of Natural Science and Technology, Department of Applied Bioscience and Biotechnology, Laboratory of Natural Products Chemistry, Okayama University, Tsushima naka 3-1-1, Okayama 700-8530, Japan. / Faculty of Agriculture, Okayama University, Tsushima naka 1-1-1, Okayama 700-8530, Japan

3. Faculty of Agriculture, Okayama University, Tsushima naka 1-1-1, Okayama 700-8530, Japan

Abstract

Abstract The activity-guided chromatographic purification of the methanol extract of Knema hookeriana, using pine wood nematodes Bursaphelenchus xylophilus has successfully led to the isolation and characterization of two phenolic antinematodal compounds with minimun effective dose (MED) of 4.5 and 20 μg/cotton ball (μg/ bl.) or 0.018 and 0.073 μᴍ/cotton ball (μᴍ/bl.), respectively. Based on their chemical and spectral properties, these compounds were determined to be 3-undecylphenol (1) and 3-(8Z-tridecenyl)-phenol (2). These compounds were isolated for the first time from this species, and 2 seems to be a novel compound.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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