Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma

Author:

Calabrese Cecilia1,Gilli Marina1,De Rosa Nicolina2,Di Crescenzo Vincenzo34,Zeppa Pio34,Vitale Carolina34,Vatrella Alessandro5

Affiliation:

1. 2Department of Cardio-Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy

2. 3AORN Ospedale dei Colli, Division of Pulmonary Oncology, Naples, Italy

3. 4AORN Ospedale dei Colli, Division of Pathology, Naples, Italy

4. 5Department of Medicine and Surgery, Section of Respiratory Disease, University of Salerno, Salerno, Italy

5. 1University of Salerno, Department of Medicine and Surgery, Baronissi Campus, Via S. Allende, Baronissi (SA), Italy

Abstract

AbstractIn this report we describe a case of pulmonary epithelioid hemangioendothelioma (PEH) in a young woman. The neoplasm manifested with dry cough, chest pain, finger clubbing, and multiple bilateral pulmonary nodules on chest x-ray and computed tomographic (CT) scan. She underwent thoracoscopy, and the histological features of the lung biopsies were initially interpreted as consistent with a not-well-defined interstitial lung disease. Our patient was clinically and radiologically stable over a period of four years, after which the disease progressed to involve not only the lung but also mediastinal lymph nodes, liver and bone. Fiberoptic bronchoscopy showed subtotal occlusion of the right middle and lower lobe bronchi. The histologic examination of bronchial biopsies revealed a poorly differentiated neoplasm immunohistochemically positive for vimentin and vascular markers CD31, CD34 and Factor VIII. A diagnosis of malignant hemangioendothelioma was made. Positron emission tomography (PET) is more sensitive than CT scan and bone scintigraphy in detecting PEH metastases. Furthermore, 18-fluorodeoxyglucose (FDG) uptake seems to be related to the grade of malignancy of PEH lesions. Therefore, we suggest that FDG-PET should be included in the staging system and follow-up of PEH.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Reference23 articles.

1. Lymph node fine needle cytology in the staging and follow - up of cutaneous lymphomas node fine needle cytology in the staging and follow - up of cutaneous lymphomasBMC Cancer;Vigliar;BMC Cancer,2014

2. Application of proteomics and peptidomics to COPD of proteomics and peptidomics to COPDBiomed Res;Pelaia;Biomed Res Int Int,2014

3. Ultrasound - guided fine needle aspiration cytology of a primary lymph node leiomyoma : a flexible procedure for a complex case - guided fine needle aspiration cytology of a primary lymph node leiomyoma : a flexible procedure for a complex caseActa Cytol;Baldi;Acta Cytol,2014

4. - cell population in a reactive lymph node in acquired immunodeficiency syndrome - cell population in a reactive lymph node in acquired immunodeficiency syndromeDiagn Cytopathol;Cozzolino;Diagn Cytopathol,2009

5. Fine - needle cytology of Hürthle cell tumors and morphometry ZeppaPVitaleMFine - needle cytology of Hürthle cell tumors and morphometryCancer Cytopathol;Zeppa;Cancer Cytopathol,2014

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3