Antidepressant alkaloids from the rhizomes of Corydalis decumbens
Author:
Ma Qin-Ge1ORCID, Tang Ye1, He Mao-Hua1, Wei Rong-Rui1ORCID
Affiliation:
1. Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine , Jiangxi University of Chinese Medicine , Nanchang 330004 , P. R. China
Abstract
Abstract
Two new alkaloids (1 and 2), named 1,7-dimethoxy-2′-prenyl-1′,9-dihydropyrrolo-carbazole (1) and 1,7-dimethoxy-4′,5′-dimethylcyclopenta-carbazole-1′,3′-dione (2), along with thirteen known alkaloids (3–15) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl3 extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (1–15) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake in vitro. Among them, compounds 1, 2, 4, and 6 showed certain antidepressant activities.
Funder
the Science and Technology Project of Jiangxi Provincial Department of Education
Publisher
Walter de Gruyter GmbH
Subject
General Biochemistry, Genetics and Molecular Biology
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