Sesquiterpenoids from <i>Tithonia diversifolia</i> (Hemsl.) A. Gray induce apoptosis and inhibit the cell cycle progression of acute myeloid leukemia cells-Reference-Cited by-同舟云学术

Sesquiterpenoids from Tithonia diversifolia (Hemsl.) A. Gray induce apoptosis and inhibit the cell cycle progression of acute myeloid leukemia cells

Published:2022-11-03 Issue:1-2 Volume:78 Page:65-72
ISSN:0939-5075
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Thuy Trinh Thi¹²^ORCID,Thuy Linh Nguyen Thi¹²^ORCID,Cham Ba Thi¹²^ORCID,Hoang Anh Nguyen Thi¹²^ORCID,Quan Tran Duc²^ORCID,Tam Nguyen Thanh¹²,Hong Nhung Le Thi³^ORCID,Thao Do Thi¹⁴^ORCID,Hung Nguyen Phi¹⁵^ORCID,Hoang Vu Dinh⁶^ORCID,Adorisio Sabrina⁷^ORCID,Delfino Domenico V.⁷⁸^ORCID

Affiliation:

1. Graduate University of Science and Technology , Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet, Nghia Do, Cau Giay , Ha Noi , Viet Nam

2. Institute of Chemistry , Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet, Nghia Do, Cau Giay , Ha Noi , Viet Nam

3. Hanoi University of Industry , 298 Cau Dien, North District Tu Liem , Ha Noi , Viet Nam

4. Institute of Biotechnology , Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet, Nghia Do, Cau Giay , Ha Noi , Viet Nam

5. Institute of Natural Products Chemistry , Vietnam Academy Science and Technology , 18 Hoang Quoc Viet, Nghia Do, Cau Giay , Ha Noi , Viet Nam

6. School of Chemical Engineering , Hanoi University of Science and Technology , 1 Dai Co Viet, Hai BBa Trung , Ha Noi , Viet Nam

7. Department of Medicine and Surgery, Foligno Nursing School , University of Perugia , Piazzale Severi, S. Andrea delle Fratte , 06129 Perugia , Italy

8. Department of Medicine and Surgery , University of Perugia , Piazzale Severi, S. Andrea delle Fratte , 06129 Perugia , Italy

Abstract

Abstract Three sesquiterpene lactones (1–3) were isolated from the aerial part of Tithonia diversifolia (Hemsl.) A. Gray grown in the Hoa Binh province in Viet Nam. The structures of these three sesquiterpene lactones were identified as tagitinin A (1), 1β-hydroxytirotundin 3-O-methyl ether (2), and tagitinin C (3) by analyzing spectroscopic data. For the first time, compound 2 was isolated from T. diversifolia growing in Viet Nam. Furthermore, contrary to existing literature, we determined that compound 1 was the major isolate. Compounds 1 and 3 significantly decreased numbers of acute myeloid leukemia OCI-AML3 cells by promoting apoptosis and causing cell cycle arrest at G0/G1 phase at concentrations as low as 2.5 μg/mL (compound 1) and 0.25 μg/mL (compound 3). Additionally, all three compounds showed cytotoxic activity against five human cancer cell lines (A549, T24, Huh-7, 8505, and SNU-1), with IC50 values ranging from 1.32 ± 0.14 to 46.34 ± 2.74 μM. Overall, our findings suggest that compounds 1 and 3 may be potential anti-cancer therapeutics and thus warrant further study.

Funder

Vietnam Academy of Science and Technology

PhD Scholarship Programme of Vingroup Innovation Foundation

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2021-0154/pdf

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