A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Author:

Van Do Truong Nhat12ORCID,Nguyen Hai Xuan12ORCID,Le Tho Huu12ORCID,Dang Phu Hoang12ORCID,Nguyen Mai Thanh12,Thi Nguyen Mai Thanh132,Nguyen Nhan Trung132

Affiliation:

1. Faculty of Chemistry, University of Science , Ho Chi Minh City , Vietnam

2. Vietnam National University , Ho Chi Minh City , Vietnam

3. Cancer Research Laboratory, University of Science , Ho Chi Minh City , Vietnam

Abstract

Abstract A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (25). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Reference16 articles.

1. Vo, VC. Dictionary of Vietnamese medicinal plants. Hanoi: Publishing House of Medicine; 2012:323 p.

2. Do, LT. Vietnamese traditional medicinal plants and drugs. Hanoi: Publishing House of Medicine; 2001:235 p.

3. Chen, IN, Chang, CC, Wang, CY, Shyu, YT, Chang, TL. Antioxidant and antimicrobial activity of Zingiberaceae plants in Taiwan. Plant Foods Hum Nutr 2008;63:15–20. https://doi.org/10.1007/s11130-007-0063-7.

4. Gupta, R, Ali, M, Eranna, D, Setty, R. Evaluation of anti-ulcer effect of root of Curcuma zedoaria in rats. Indian J Tradit Knowl 2003;2:375–7.

5. Lee, TK, Lee, D, Lee, S, Ko, YJ, Kang, KS, Chung, SJ, et al.. Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells. Bioorg Chem 2019;87:117–22. https://doi.org/10.1016/j.bioorg.2019.03.015.

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