Prostaglandin Synthesis Inhibitors Reduce Cannabis and Restraint Stress Induced Increase in Rat Brain Serotonin Concentrations

Abstract

Cannabis resin (Cl) produced a dose-related increase in rat brain serotonin concentrations, whereas restraint stress produced maximal rise of the neurotransmitter concentrations at 1 h, followed by a tendency to normalise by 4 h. The prostaglandin (PG) synthesis inhibitors, diclofenac and paracetamol, antagonized Cl and restraint stress induced rise in serotonin concentrations. The findings lend credence to earlier reports that PG synthesis inhibitors antagonize serotonin-mediated neuropharmacological actions of Cl and restraint stress in rats