Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction-Reference-Cited by-同舟云学术

Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction

Published:2022-02-22 Issue:4 Volume:110 Page:259-265
ISSN:0033-8230
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Hussien Heba¹²,Khater Sabah I.¹³,Rashad Ahmed M.⁴⁵

Affiliation:

1. Cyclotron Project, Nuclear Research Center , Egyptian Atomic Energy Authority (EAEA) , P.O. Box 13759 , Cairo , Egypt

2. Labeled Compounds Department, Hot Labs. Center , Egyptian Atomic Energy Authority (EAEA) , P.O. Box 13759 , Cairo , Egypt

3. Radioactive Isotopes and Generators Department, Hot Lab. Center , Egyptian Atomic Energy Authority (EAEA) , P.O. Box 13759 , Cairo , Egypt

4. Accelerators and Ion Sources Department, Nuclear Research Center , Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

5. Central Laboratory for Elemental and Isotopic Analysis, NRC , Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

Abstract

Abstract The current study is an attempt to confirm the possibility of using rafoxanide (Raf) for diagnostic or radiotherapeutic purpose based on the radioiodine used in the labeling process. The isotopic exchange reaction was performed to radiolabel Raf. The maximum radiochemical yield of [125I]Raf (90%) was obtained when 20 μL of Na[125I]I (7.4 MBq (200 μCi)) in the reaction flask was added to 100 μg of Raf (0.799 mM) within 20 min at 140 °C. High pressure liquid chromatography was used to purify the labeled product of [125I]Raf. The activation energy was calculated experimentally in both ethyl acetate and methanol as reaction medium and found to be 22.82 kJ/mol and 24.43 kJ/mol, respectively. Furthermore, Gaussian 09 used the density function theory (DFT) to calculate the activation energy of the reaction in the two solvents.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2022-0009/pdf

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