Radioiodination and biological evaluation of irbesartan as a tracer for cardiac imaging
Author:
Sanad M. H.1, Marzook F. A.1, Abd-Elhaliem S. M.1
Affiliation:
1. Labeled Compounds Department , Hot Labs Center, Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt
Abstract
Abstract
Irbesartan was labeled using 125I or 131I with N-bromosuccinimide (NBS) as an oxidizing agent. A lot of operators such as, quantity of substrate, the quantity of oxidizing agent, reaction temperature, reaction time, and pH of reaction medium were studied to optimize high radiochemical yield of [125I]IodoIrbesartan ([125I]Irb.). The preclinical evaluation of IodoIrbesartan in experimental mice indicated high accumulation in target organ of heart with a high heart/blood ratio of 12.85 at 30 min post-injection. This study indicates the suitability of [125I]IodoIrbesartan ([125I]Irb.) for cardiac imaging.
Publisher
Walter de Gruyter GmbH
Subject
Physical and Theoretical Chemistry
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