Special radionuclide production activities – recent developments at QST and throughout Japan
Author:
Nagatsu Kotaro1, Ohya Tomoyuki1, Obata Honoka12, Suzuki Kazutoshi1, Zhang Ming-Rong1
Affiliation:
1. Department of Advanced Nuclear Medicine Sciences , Institute for Quantum Medical Sciences (iQMS), National Institutes for Quantum Science and Technology (QST) , 4-9-1 Anagawa, Inage , Chiba 263-8555 , Japan 2. Graduate School of Pharmaceutical Sciences, Hokkaido University , N8W5, Kita , Sapporo , Hokkaido 060-0808 , Japan
Abstract
Abstract
National Institutes for Quantum Science and Technology (QST), formerly known as the National Institute of Radiological Sciences (NIRS), has been engaged in work on radiopharmaceutical science using cyclotrons since 1974. Eight pioneering researchers founded the basis of this field of research at NIRS, and to the present, many researchers and technicians have accumulated both scientific and technical achievements, as well as inherited the spirit of research. Besides, in recent years, we have developed production systems with AVF-930 cyclotron for various ‘non-standard’ radioisotopes applied in both diagnosis and therapy. Here, we review the past 50 years of our activities on radioisotope and radiopharmaceutical development, as well as more recent activities.
Publisher
Walter de Gruyter GmbH
Subject
Physical and Theoretical Chemistry
Reference112 articles.
1. Fukuda, N., Tateno, Y., Rikitake, T., Matsumoto, T., Tomitani, T., Suzuki, K., Koen, H., Musha, H., Okuda, K. Coincidence positron imaging of the liver and heart following rectal administration of 13N-ammonia in liver cirrhosis. Radioisotopes 1977, 26, 872–875; https://doi.org/10.3769/radioisotopes.26.12_872. 2. Kashida, Y., Suzuki, K., Iwata, R., Yoshikawa, K., Tamate, K. Safety handling for cyclotron production of radiopharmaceuticals. J. Label. Compd. 1977, 13, 192. 3. Ido, T., Wan, C-N., Casella, V., Fowler, J. S., Wolf, A. P., Reivich, M., Kuhl, D. E. Labeled 2-deoxy-D-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-D-glucose, 2-deoxy-2-fluoro-D-mannose and 14C-2-deoxy-2-fluoro-D-glucose. J. Label. Compd. Radiopharm. 1977, 14, 175–183. 4. Ido, T., Wan, C-N., Fowler, J. S., Wolf, A. P. Fluorination with F2. A convenient synthesis of 2-deoxy-2-fluoro-D-glucose. J. Org. Chem. 1977, 42, 2341–2342; https://doi.org/10.1021/jo00433a037. 5. Reivich, M., Kuhl, D., Wolf, A., Greenberg, J., Phelps, M., Ido, T., Casella, V., Fowler, J., Hoffman, E., Alavi, A., Som, P., Sokoloff, L. The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ. Res. 1979, 44, 127–137; https://doi.org/10.1161/01.res.44.1.127.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|