Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes-Reference-Cited by-同舟云学术

Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes

Published:2021-05-13 Issue:0 Volume:0 Page:
ISSN:2193-3405
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Hassan Hishar¹,Othman Muhammad Faiz²,Abdul Razak Hairil Rashmizal¹³

Affiliation:

1. Centre for Diagnostic Nuclear Imaging , Universiti Putra Malaysia , 43400 UPM Serdang , Selangor , Malaysia

2. Department of Pharmacy Practice, Faculty of Pharmacy , Universiti Teknologi MARA , 42300 Bandar Puncak Alam , Selangor , Malaysia

3. Department of Imaging, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , 43400 UPM Serdang , Selangor , Malaysia

Abstract

Abstract 18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [18F]AlF-bifunctional chelator technique. As well as being simple, the suggested method is practical and relevant for beginners interested in 18F-fluorination with [18F]AlF-chelate complex technique or also for a researcher who aims to proceed on an extensive scale.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2021-1024/pdf

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