[<sup>113m</sup>In]In-PSMA: high potential agent for SPECT imaging of prostate cancer-Reference-Cited by-同舟云学术

[^113mIn]In-PSMA: high potential agent for SPECT imaging of prostate cancer

Published:2024-09-04 Issue: Volume: Page:
ISSN:0033-8230
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Akbari Leyla¹,Sina Sedigheh¹,Zolghadri Samaneh²,Moghaddasi Ali³,Hadad Kamal¹,Yousefnia Hassan²

Affiliation:

1. Radiation Application Department, School of Mechanical Engineering , Shiraz University , Shiraz , Iran

2. Radiation Application Research School , Nuclear Science and Technology Research Institute (NSTRI) , Tehran , 14155-1339 , Iran

3. Shahid Beheshti University , Tehran , Iran

Abstract

Abstract The prevalence rate of prostate cancer is very high and unfortunately causes many deaths worldwide. This study aimed to prepare [113mIn]In-PSMA as a novel agent for single photon emission computed tomography (SPECT) imaging of prostate cancer. 113mIn was eluted from an in-house made 113Sn/113mIn generator in chloride form, and its radionuclide, chemical and radiochemical purities was studied. [113mIn]In-PSMA was prepared with radiochemical purity (RCP) > 99 % under optimal labeling conditions. The biodistribution of the labeled compound was studied in normal rats, showed the major activity in the urine and kidneys as the main excretion route from the body. Considerable uptake was observed in the prostate and salivary glands as the PSMA-expressing organs. These data are in complete agreement with the other published data on PSMA-labeled compounds both in animals and humans. The results demonstrated [113mIn]In-PSMA can be considered as a good option for SPECT imaging of prostate cancer.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/ract-2024-0298/pdf

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