A New Benzo-γ-pyran Derivative Isolated from Propolis-Reference-Cited by-同舟云学术

A New Benzo-γ-pyran Derivative Isolated from Propolis

Published:1998-12-01 Issue:11-12 Volume:53 Page:1037-1039
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Matsuno Tetsuya¹,Saito Masahiro²,Matsumoto Yasuyuki²,Morikawa Junji²

Affiliation:

1. Institute of Cancer Research, Columbia University, 701 West 168th Street, New York, NY 10032, USA

2. Eiken Chemical Co., Ltd. 1 -3 3 -8 Hongo, Bunkyo-ku, Tokyo 113, Japan

Abstract

Abstract The methanol extract of Brazilian propolis was fractionated by HPLC, based on human hepatocellular carcinoma (HuH 13) cell cytotoxicity assay. A new benzo-y-pyran derivative (PM-3) with a molecular formula of C19H22O3 (MW: 298.38) was isolated. The structure of this colorless compound was determined as 3-[2-dimethyl-8-(3-methyl-2-butenyl) benzopy-ran]-6 -propenoic acid. This compound was chemically synthesized by cyclisation of artepillin C (3-[4-hydroxy-3,5-bis (3-methyl-2-butenyl) phenyl]-2-propenoic acid).

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-1998-11-1215/pdf

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