A New Bromotyrosine Alkaloid from the Caribbean Sponge Aiolochroia crassa

Author:

Assmann Michael12,Wray Victor3,van Soest Rob W. M.4,Proksch Peter1

Affiliation:

1. Julius-von-Sachs-Institut für Biowissenschaften, Lehrstuhl für Pharmazeutische Biologie, Universität Würzburg, Julius-von-Sachs-Platz 2, D-97082 Würzburg, Germany

2. Institut für Organische Chemie der Jo hann Wolfgang Goethe-Universität, Marie-Curie- Straße 11. D-60439 Frankfurt am Main, Germany

3. Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany

4. Instituut voor Systematiek en Populatiebiologie, Zoologisch Museum, P. O. Box 94766. Universiteit van Amsterdam, 1090 G T Amsterdam, The Netherlands

Abstract

Abstract A detailed analysis of the chemical constituents of a Caribbean specimen of Aiolochroia crassa was performed. Five brominated products (1 -5) were isolated and one of these was a new bromotyrosine metabolite. The structure of the new compound 1 has been established from spectral studies. Compounds 1 and 2, which are the major brominated metabolites and have not been previously identified in any Aiolochroia species, could be usefully employed as chemotaxonomic markers.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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