Fetal intracranial hemorrhage in a case of 16p microdeletion
Author:
Álvarez-de-la-Rosa Rodríguez Margarita1ORCID, Hernández-Suárez Mercedes1, Padilla-Pérez Ana Isabel1, Dévora-Cabrera Ylenia1, Plasencia Acevedo Walter1
Affiliation:
1. Obstetrics and Gynecology Service , Hospital Universitario de Canarias , La Laguna , Tenerife, Canary Islands , Spain
Abstract
Abstract
Objectives
Intracranial hemorrhages are common events in premature infants but in fetal life those incidents are often of ominous prognosis and unknown etiology.
Case presentation
We present the diagnosis, evolution and management of a fetal hemorrhagic accident associated with an inherited maternal microdeletion of the chromosome 16 short arm. Abnormal neurosonography in routine second trimester ultrasound led to follow up. Fetal germinal matrix hemorrhage along with severe asymmetric ventriculomegaly and a secondary periventricular cyst developed in the early third trimester. Array CGH showed microdeletion 16p11.2.
Conclusions
This microdeletion had not been previously associated with fetal intracranial hemorrhage.
Publisher
Walter de Gruyter GmbH
Subject
Obstetrics and Gynecology,Embryology,Pediatrics, Perinatology and Child Health
Reference11 articles.
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