Author:
Balouzet Clara,Chanat Cédric,Jobard Marion,Brandely-Piat Marie-Laure,Chast François
Abstract
AbstractAzacitidine is supplied as lyophilized powder to be reconstituted with sterile water for injection. The molecule is very unstable in aqueous medium (temperature-dependent process). Advance preparation and leftover management are made difficult by such poor stability. This study evaluates the stability of 25 mg/mL azacitidine suspensions kept for a 1-month period at –20 °C, followed by a 5-day period at 5 °C. Three batches of 7 polypropylene syringes were filled with 2 mL of Vidaza
Subject
Pharmacology (medical),Pharmacology,Pharmacy
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