Investigation of optical and biocompatible properties of polyethylene glycol-aspirin loaded commercial pure titanium for cardiovascular device applications

Abstract

Abstract This research investigates the optical and biocompatible properties of alkali-treated cpTi immersed in aspirin and different molecular weights of polyethylene (PEG). Instrumental characterizations were performed using scanning electron microscopy (SEM), Raman spectroscopy, and ultraviolet–visible spectroscopy. Additionally, drug release, antithrombotic, and cell adhesion studies were conducted in in-vitro conditions. The SEM micrographs showed that heat treatment of NaOH modified cpTi substrates increased the average surface pore size by 217%. Raman spectra’s active modes confirmed the presence of titanate groups which intensified the semiconductive nature of alkali-treated cpTi substrates. Further, the semiconductive nature was confirmed through the shift of the energy bandgap from 2.69 to 2.9 eV. The continuous redshift of the absorbance edge with an increase in the molecular weight of PEG indicates improved optical property. Following the Rigter–Peppas dynamic model, the drug release kinetics showed a non-Fickian dispersion (n < 1) and super case II transport (n = 2.21) for PEG-coated cpTi substrates. The alkali-treated cpTi-aspirin-PEG surface exhibits suitable antithrombotic property and interstitial cell adhesion with PEG coating. The modified surface on cpTi demonstrated a promising technique to improve the optical, antithrombotic, and biocompatibility performances, which are the prime requirement for the blood-interacted cardiovascular devices such as stents.