Preparation and properties of vancomycin-loaded PLA-PEG-PLA microspheres by electrostatic spray technology
Author:
Tang Ruimin1, Feng Yan2, Chen Rongying1, Yuan Minglong1, Yuan Mingwei1, Li Hongli1, Jiang Dengbang1
Affiliation:
1. National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials , 145309 Yunnan Minzu University , Kunming 650500 , China 2. Yunnan ICL YTH Phosphate Research and Technology Center CO., LTD , Kunming 650100 , China
Abstract
Abstract
Vancomycin in sustained release still needs to be investigated. Polylactic acid (PLA) was widely used in the biomedical field for its good biocompatibility, especially in the field of controlled drug release. In this study, polyethylene glycol (PEG) was used to modify PLA to improve the hydrophilicity of the material. The synthesis of the block copolymers was proven by infrared and nuclear magnetic characterization and the hydrophilicity was tested. Vancomycin was immobilized by coaxial electrospray, and PLA-PEG6000-PLA was used as the shell layer. The parameters of coaxial electrospray under this material were explored, and the effects of concentration, voltage and temperature on the formation of microspheres were systematically studied. The optimum parameters were determined as follows: concentration 20 wt%, temperature 35 °C and voltage 14 kV. The maximum encapsulation rate and drug loading were calculated to be 89.54 ± 1.22 % and 15.33 ± 0.97 %, respectively, and the cumulative release of drug-loaded microspheres was less than 45 % in 24 h with a slow releasing time of more than one month. The drug loaded microspheres showed good sustained release and good control of burst release.
Funder
Yunnan minzu University 2022 Master’s Research Innovation Fund Project National Natural Science Foundation of China Yunnan Ten Thou-sand Talents Program-Special Program for Top Young Talents Yunnan Province Basic Research Project
Publisher
Walter de Gruyter GmbH
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