CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients
Author:
Zihlif Malek1, Abusara Osama H.2ORCID, Al-Qerem Walid2ORCID, Al-Ibadah Mahmood2, Mahafza Tareq M.3, Al-Akhras Fatima M.4, Mahafza Naseem T.3
Affiliation:
1. Department of Pharmacology , School of Medicine, The University of Jordan , Amman , Jordan 2. Department of Pharmacy , Faculty of Pharmacy, Al-Zaytoonah University of Jordan , Amman , Jordan 3. Department of Special Surgery , School of Medicine, The University of Jordan , Amman , Jordan 4. Molecular Biology Research Laboratory , School of Medicine, The University of Jordan , Amman , Jordan
Abstract
Abstract
Objectives
Rhinitis is classified into several types with allergic rhinitis (AR) being the most common. AR is among the inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), in which corticosteroids are administered to overcome the decrease in cortisol production. The treatment options available for AR vary with 1st line treatment being intranasal corticosteroids (INCS). The responsiveness to corticosteroids is due to their binding to corticotropin-releasing hormone receptor-1 (CRHR1). Various studies have studied the responsiveness to corticosteroids treatment in patients with asthma and COPD in association with CRHR1 gene single nucleotide polymorphisms (SNPs).
Methods
In our study, we investigated the association of three SNPs of CRHR1 gene (rs242941, rs242940, and rs72834580) with symptoms improvement post-treatment in AR patients. Blood samples were collected from 103 patients for DNA extraction and gene sequencing. Those patients started to receive INCS for 8 weeks and their symptoms were assessed, through a questionnaire, before treatment and post-treatment to check for symptoms improvement.
Results
Our data showed that improvement of eye redness is significantly less following INCS treatment in patients with allele (C) (AOR=0.289, p-value-0.028, 95 % CI=0.096–0.873) and genotype (CC) (AOR=0.048, p-value-0.037, 95 % CI=0.003–0.832) of rs242941 SNP. There was no correlation with other genotypes, alleles, or haplotypes of the investigated SNPs.
Conclusions
Our findings show that there is no correlation between CRHR1 gene polymorphism and symptoms improvement following INCS treatment. Further studies are required to evaluate the association of INCS and symptoms improvement post-treatment with larger sample size.
Funder
Al-Zaytoonah University of Jordan
Publisher
Walter de Gruyter GmbH
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
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