Pharmacogenetic predictors of development of secondary to enalapril dry cough in hypertensive patients-Reference-Cited by-同舟云学术

Pharmacogenetic predictors of development of secondary to enalapril dry cough in hypertensive patients

Published:2023-05-19 Issue:3 Volume:38 Page:247-254
ISSN:2363-8915
Container-title:Drug Metabolism and Personalized Therapy
language:en
Short-container-title:

Author:

Sychev Ivan V.¹²^ORCID,Denisenko Natalia P.³^ORCID,Kachanova Anastasiya A.⁴^ORCID,Lapshtaeva Anna V.⁵^ORCID,Goncharova Ludmila N.¹^ORCID,Mirzaev Karin B.⁶^ORCID,Sychev Dmitry A.⁷^ORCID

Affiliation:

1. Department of Faculty Therapy with Courses of Physiotherapy, Physical Therapy , Ogarev Mordovia State University , Saransk , Russian Federation

2. 68, Bolshevitskaya Street , Saransk , Republic of Mordovia , 430005 , Russia

3. Research Institute of Molecular and Personalized Medicine, Department of Clinical Pharmacology and Therapy named after Academician B.E. Votchal, Russian Medical Academy of Continuous Professional Education , Moscow , Russia

4. Predictive and Prognostic Biomarkers Department , Russian Medical Academy of Continuous Professional Education , Moscow , Russia

5. Department of Immunology, Microbiology and Virology with a course of clinical immunology and allergology , Ogarev Mordovia State University , Saransk , Russian Federation

6. Research and Innovation, Research Institute of Molecular and Personalized Medicine, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation , Moscow , Russia

7. Clinical Pharmacology and Therapy Department named after Academician B.E. Votchal , Russian Medical Academy of Continuous Professional Education , Moscow , Russia

Abstract

Abstract Objectives Development of the secondary to ACEI cough leads to discontinuation of the drugs of this group. Assessing the safety of the ACEIs with further development of customized approaches for their administration is a major scientific and practical problem. The objective of this study was to assess the association of the genetic markers with the development of the adverse drug reaction in the form of secondary to enalapril dry cough in the patients with essential arterial hypertension. Methods Study involved 113 patients with the secondary to enalapril cough and 104 patients without development of the secondary to enalapril adverse drug reaction. Results The patients carriers of the genotype AA rs2306283 of gene SLCO1B1 had 2-fold higher odds of developing the dry cough than those with the genotypes AG and GG (ОR=2.01, 95%CI=1.10–3.66, р=0.023). Similarly, the patients heterozygous for rs8176746 of gene АВО had 2.3-fold higher odds of developing the ADR in the form of dry cough than the carriers of the genotypes GG and TT (ОR=2.30, 95%CI=1.24–4.29, р=0.008). Conclusions Statistically significant association between the development of the ADR in the form of secondary to enalapril dry cough and polymorphisms rs2306283 of gene SLCO1B1 and rs8176746 of gene ABO was revealed.

Publisher

Walter de Gruyter GmbH

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

https://www.degruyter.com/document/doi/10.1515/dmpt-2023-0008/pdf

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